HMGBiotech 高遷移率蛋白、質(zhì)粒、抗體-相關(guān)技術(shù)文章

更新時間：2024-07-20

瀏覽次數(shù)：891

HMGBiotech 高遷移率蛋白、質(zhì)粒、抗體

HMGBiotech公司簡介

HMGBiotech公司研發(fā)的HMGB 1是細(xì)胞核的一個組成部分，在基因組的組織和表達(dá)中具有多種功能。HMG生物技術(shù)SRL為活躍在這一領(lǐng)域的其他研究人員和公司提供試劑、服務(wù)和想法。它還有助于比安奇實(shí)驗(yàn)室開發(fā)分析和試劑。

HMGBiotech是一家生物技術(shù)公司，由HMGB領(lǐng)域的 ling xian 科學(xué)家Marco E. Bianchi創(chuàng)立。

HMGBiotech是唯yi一家生產(chǎn)HMGB1質(zhì)量控制氧化還原變體的生產(chǎn)商。該公司為活躍于這一有前途領(lǐng)域的其他研究人員和公司提供試劑、服務(wù)和想法，并幫助 Bianchi 實(shí)驗(yàn)室開發(fā)檢測方法和試劑。

HMGB1是細(xì)胞核的一個組成部分，在基因組的組織和表達(dá)中具有多種功能。當(dāng)細(xì)胞因損傷（病毒、機(jī)械或化學(xué)創(chuàng)傷、中毒）而死亡時，HMGB1 被釋放并被附近細(xì)胞中的受體吸收。此外，處于嚴(yán)重壓力下的細(xì)胞甚至在死亡前就會分泌HMGB1。存活的細(xì)胞會發(fā)出一線反應(yīng) - 炎癥 - 并試圖替換死細(xì)胞并重建受損組織。HMGB1 促進(jìn)恢復(fù)和再生，例如梗死后心臟的恢復(fù)和再生。然而，過多的 HMGB1 與膿毒癥（過度炎癥導(dǎo)致急性痛苦并最終死亡）、關(guān)節(jié)炎、動脈粥樣硬化和癌癥轉(zhuǎn)移有關(guān)。

anti HMGB1單克隆抗體

小鼠單克隆 IgG1 DPH1.1 是通過向 C57BL/6 小鼠注射 17 聚體肽 P1 （KGKPDAAKKGVVKAEKS）產(chǎn)生的。雜交瘤通過標(biāo)準(zhǔn)技術(shù)從脾細(xì)胞中產(chǎn)生，并通過 ELISA 針對免疫原和全長 HMGB1 進(jìn)行測試。

DPH1.1 mAb 可識別所有哺乳動物 HMGB1，包括人、小鼠和大鼠。無法識別 HMGB2。

DPH1.1 mAb 可用于蛋白質(zhì)印跡（WB）。

DPH1.1 mAb 在跨孔遷移試驗(yàn)中阻斷 HMGB1 誘導(dǎo)的細(xì)胞遷移。

在體內(nèi)，靜脈內(nèi)施用 DPH1.1 mAb （220 μg/小鼠）可阻斷炎癥細(xì)胞募集到壞死和感染部位。

本產(chǎn)品僅供研究使用，不能用于人體。

HMGBiotech公司熱銷產(chǎn)品

產(chǎn)品名稱	貨號	規(guī)格
100 ug Fully reduced HMGB1, LPS free	HM-115	100 ug
50 ug Fully reduced HMGB1, LPS free	HM-116	50 ug
100 ug Disulfide HMGB1, LPS free	HM-121	100 ug
100 ug BoxA from HMGB1, LPS-free and tested in migration assay	HM-012	100 ug
50 ug Disulfide HMGB1, LPS free	HM-122	50 ug
500 ug BoxA from HMGB1, LPS-free and tested in migration assay	HM-013	500 ug
1 mg HMGB1 for biochemistry	HM-100	1 mg
2.5 mg BoxA from HMGB1, LPS-free and tested in migration assay	HM-014	2.5 mg
250 ug HMGB1 biochemistry	HM-101	250 ug
25 ug BoxA from HMGB1, LPS-free and tested in migration assay	HM-011	25 ug
15 ug BoxB from HMGB1, LPS-free and tested in migration assay	HM-053	15 ug
15 ug Fully reduced HMGB1, LPS free	HM-117	15 ug
10 ug Disulfide HMGB1, LPS free	HM-123	10 ug
15 ug Non-oxidizable HMGB1, LPS free	HM-133	15 ug
250 ug Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) tested in migration	HM-170	250 ug
100 ug Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) tested in migration	HM-171	100 ug
50 ug Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) tested in migration	HM-172	50 ug
15 ug Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) tested in migration	HM-173	15 ug
50 ug HMGB1 15N labelled for Mass Spectrometry	HM-180	50 ug
5 ug HMGB1 15N labelled for Mass Spectrometry	HM-181	5 ug
2.5 mg BoxA 2D from HMGB1, LPS-free and tested in migration assay	HM-190	2.5 mg
500 ug BoxA 2D from HMGB1, LPS-free and tested in migration assay	HM-191	500 ug
100 ug BoxA 2D from HMGB1, LPS-free and tested in migration assay	HM-192	100 ug
25 ug BoxA 2D from HMGB1, LPS-free and tested in migration assay	HM-193	25 ug
Control cell lysates from Hmgb1 +/+	HM-001	請咨詢
Control cell lysates from Hmgb1 -/-	HM-002	請咨詢
1 mg BoxB from HMGB1, LPS-free and tested in migration assay	HM-050	1 mg
250 ug BoxB from HMGB1, LPS-free and tested in migration assay	HM-051	250 ug
100 ug BoxB from HMGB1, LPS-free and tested in migration assay	HM-052	100 ug
500 ug Fully reduced HMGB1, LPS free	HM-114	500 ug
250 ug Disulfide HMGB1, LPS free	HM-120	250 ug
500 ug Non-oxidizable HMGB1, LPS free	HM-130	500 ug
100 ug Non-oxidizable HMGB1, LPS free	HM-131	100 ug
50 ug Non-oxidizable HMGB1, LPS free	HM-132	50 ug
500 ug HMGB2, LPS-free and tested in migration assay	HM-151	500 ug
100 ug HMGB2, LPS-free and tested in migration assay	HM-152	100 ug
50 ug HMGB2, LPS-free and tested in migration assay	HM-153	50 ug
Embryonic fibroblasts immortalized with large T antigen. One vial of -/- cells and one vial of +/+ cells	HM-201	2管
Embryonic fibroblasts immortalized with the 3T3 method. One vial of -/- cells and one vial of +/+ cells	HM-221	2管
Embryonic fibroblasts, Hmgb1-/- and HMGB2-low, immortalized with the 3T3 method. One vial of cells, and	HM-223	2管
HMGB1 Isoforms Kit - Test size	HM-030	請咨詢
Embryonic fibroblasts immortalized with the 3T3 method. One vial of Hmgb2-/- cells and one vial of +/+ cells	HM-251	2管
HMGB1 Isoforms Kit - Regular size	HM-031	請咨詢
20 ug p-mHMG1	HM-300	20 ug
50 ug Terminally oxidized HMGB1, LPS free	HM-062	50 ug
20 ug p-mHMG1tag	HM-301	20 ug
100 ug Terminally oxidized HMGB1, LPS free	HM-061	100 ug
20 ug pEGFP-HMGB1	HM-302	20 ug
250 ug Terminally oxidized HMGB1, LPS free	HM-060	250 ug
20 ug pcDNA/FL-RAGE plasmid	HM-310	20 ug